Antigen carbohydrate compounds and their use in immunotherapy

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241931, 4241941, 4241981, 5361231, 536123, A61K 39385, A61K 3900, C09B 4704

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active

059895527

ABSTRACT:
Conjugates between one or more repeated subunits of an antigen and a carbohydrate polymer are desired. Also described are immunogenic vaccines against disease states which contain the conjugates and methods for inducing cell-mediated immune responses. The conjugates may especially contain polymers of the carbohydrate mannose and one or more repeated subunits of human mucin.

REFERENCES:
patent: 4720386 (1988-01-01), McCollester
patent: 5047227 (1991-09-01), Rodwell et al.
Karanikas et al., "Antibody and T Cell Responses of Patients with Adenocarcinoma . . . ," J Clin Invest 100: 2783-2792 (1997).
Mitchell, "T-Cell-mediated immunity to Carunoembryonic Antigen . . . ," J Natl. Cancer Institute 87: 949-951 (1995).
Tsang et al., "Generation of Human Cytotoxic T Cells Specific . . . ," J Natl. Cancer Institute 87: 982-990 (1995).
Scholm et al., "Strategies for the Development of Recombinant . . . ," Breast Cancer Research & Treatments 38:27-39 (1996).
Ellis Chapter 29 in Vaccines Plotkin et al Eds, W B Saunders Co. Philadelphia, 1988, pp. 568-575.
Keith Jerome et al., Cancer Research, 51: 2908-2916 (Jun. 1, 1991).
J. Darrell Fentonot et al., Cancer Research, 53: 5386-5394 (Nov. 15, 1993).
Donna L. Barnd et al., Proc. Natl. Acad. Sci. USA, 86: 7159-7163 (Sep., 1989).
Franz-Georg Hanisch et al., J. Biol. Chem., 264: 872-883 (Jan. 15, 1989).
Keth Jerome et al., Cancer Research, 52: 5985-5990 (Nov. 1, 1992).
D. J. McCool et al., Biochemical Journal, 267: 491-500 (1990).
El-Nasir Lalani et al., J. Biol. Chem., 266:15420-15426 (1991).
Peter L. Devine et al., Cancer Research, 51: 5826-5836 (Nov. 1, 1991).
Okawa et al J. Immunological Methods 149:127-131 (1992).
Ada in fundamentals of Immunology 2nd Ed. Chapter 36 pp. 985-1032 William Paul Ed.
T. Nurmukhamedov et al., Immunologiya, 4: 61-63 (1991) [See English abstract at p. 63].
Tracey Langsdale, Inpharma Weekly, 915: 3-4 (1993).
V. Apostolopoulos et al., Proceedings of the National Academy of Science of USA, 92: 10128-10132 (1995).
V. Apostolopoulos et al., "Production of Anti-Breast Cancer Monoclonal Antibodies Using a Glutathione-s-transferase-MUC1 Bacterial Fusion Protein", Br. J. Cancer, 67: 713-720 (1993).
Ding, Lei et al., "Immunogenicity of Synthetic Peptides Relates to the Core Peptide Sequence Encoded by the Human MUC1 Mucin Gene: Effect of Immunization on the Growth of Murine Mammary Adenocarcinoma Cells Transfected with the Human MUC1 Gene", Cancer Immunology Immunotherapy, 36: 9-17 (1993).
Denton, G., "Induction of Antibody Responses to Breast Carcinoma Associated Mucins Using Synthetic Peptide Constructs as Immunogens", Cancer Letters, 70: 143-150 (1993).
Hudecz, F. et al., "Monoclonal Antibody Binding to Peptide Epitopes Conjugated to Synthetic Branched Chain Polypeptide Carriers", Journal of Immunological Methods, 147: 201-210 (1992).
Okawa, Y. et al., J. Immunol. Meth., "Production of anti-peptide specific antibody in mice following immunization with peptides conjugated to mannan", 149: 127-31 (1992).

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