Antigen binding molecules that bind EGFR, vectors encoding...

Details Antigen binding molecules that bind EGFR, vectors encoding... Antigen binding molecules that bind EGFR, vectors encoding...

2007-08-17

2010-06-01

Huynh, Phuong (Department: 1644)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C536S023530, C530S388100, C530S388220, C435S252330, C435S320100, C435S326000

Reexamination Certificate

active

07727741

ABSTRACT:
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.

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