Antigen-based heteropolymers and method for treating autoimmune

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...

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4241531, 5303883, 5303896, 5303911, 5303917, A61K 39395, C07K 1600

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active

058796797

ABSTRACT:
Constructs consisting of antigen-based heteropolymers (AHP's) are provided. The antigen-based heteropolymers comprise at least one monoclonal antibody specific for binding to complement receptor (CR1) site on a human or non-human primate erythrocyte, and the anti-CR1 monoclonal antibody is crosslinked to an antigen specific for a target pathogenic autoantibody. Further provided is a method for treating autoimmune diseases in human or non-human primates using the AHP.

REFERENCES:
Liszewski et al., The Complement System, Fundamental Immunology, edited by W. E. Paul, Raven Press, Ltd., New York, see p. 926, paragraph bridging cols. 1 and 2), 1993.
Taylor et al., In vivo binding and clearance of circulating antigen by bispecific heteropolymer-mediated binding to primate erythrocyte complement receptor, J. of Immunol., vol. 148. 2462-2468, see p. 2462, second col., second full paragraph, Apr. 1992.
Kimberly et al., In Vivo Handling of Soluble Complement Fixing Ab/dsDNA Immune Complexes in Chimpanzees, J. Clin. Invest. vol. 84, 962-970, see Abstract, p. 967, first col., first full paragraph, Sep. 1989.
Emlen et al., A new ELISA for the detection of double-stranded DNA antibodies, J. Immunol. Methods, 132, 91-101, see Abstract, May 1990.

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