Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1994-09-16
1999-04-06
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241841, 514 14, 514 12, 514 2, 530350, 530324, 530327, A61K 3900, A61K 3800, C07K 706, C07K 1400
Patent
active
058914374
ABSTRACT:
A 69 kD protein, designated PM-1, is expressed in human pancreatic islet cells and a human insulinoma. The amino acid sequence of the protein has been determined. Autoantibodies to the PM-1 protein have been found in sera of prediabetic patients. Natural, synthetic or recombinant forms of the PM-1 protein can be used in immunochemical assays to detect anti-PM-1-autoantibodies and to identify patients at risk of developing diabetes.
REFERENCES:
patent: 4612365 (1986-09-01), Birr et al.
patent: 4681760 (1987-07-01), Fathman
patent: 4761371 (1988-08-01), Bell et al.
patent: 4904481 (1990-02-01), Fathman
patent: 4904482 (1990-02-01), Fathman
patent: 5114844 (1992-05-01), Cohen et al.
Martin, J.M. et al. (1991) "Milk Proteins in the Etiology of Insulin-Dependent Diabetes Mellitus (IDDM)" Annals of Medicine 23: 447-452.
Baekkeskov, S. et al. (1990) "Identification of the 64K Autoantigen in Insulin-Dependent Diabetes as the GABA-synthesizing Enzyme Glutamic Acid Decarboxylase" Nature 347:151-156.
Dotta et al. (1988) "A Novel Neuroendocrine Cell Surface Glycoprotein: Identification, Isolation, and Initial Characterization" Endocrinology 122(4):1263-1268.
Eisenbarth, G.S. (1986) "Type I Diabetes Mellitus" New Eng. J. Medicine 314:1360-1368.
Erlander et al. (1991) "Two Genes Encode Distinct Glutamate Decarboxylases" NEURON 7:91-100.
Hirayama et al (1990) "Rapid Confirmation and Revision of the Primary Structure of Bovine Serum Albumin by Esims and Frit-Fab LC/MS" Biochemical and Biophysical Research Communications 173(2):639-646.
Houssaint E. et al. "Monoclonal Autoantibodies From Insulin-Dependent Diabetic Patients: Autoantibodies Against .beta.-Cell Surface of Cytoplasmic Antigens" Clinical Experimental Immunology, 82:44-51.
Hunkapiller, et al. (1983) "Isolation of Microgram Quantities of Proteins From Polyacrylamide Gels for Amino Acid Sequence Analysis" Methods in Emzymology 91:227-237.
Jaye et al. (1983) "Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-Base Synthetic Oligonucleotide probe deduced from the amino acid sequence of bovine factor IX" Nuc. Acid. Res. 11(8):2325-2335.
Laver et al. "Epitopes on Protein Antigens: Misconceptions and Realities" Cell 61:553-556.
Michelsen et al. (1991) "Cloning, Characterization, and Autoimmune Recognition of Rat Islet Glutamic Acid Decarboxylase In Insulin-Dependent Diabetes Mellitus" Proceedings of the National Academy of the Sciences 88:8754-8758.
Morein (1990) "The Iscom: An Immunostimulating System" Immunol. Letters 25:281-284.
Palmer, J.P. et al. (1983) "Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment" Science 222:1337-1339.
Petrov et al. (1990) "Modelling of type 1 diabetes with monoclonal antibody ICA-1" Biomedical Science 1:144-150.
Petrov R.V. et al. (1990) "Approaches to Immunodiagnostics IDDM Based on pp. 64-69 Beta-Cell Antigen Family and Corresponding Monoclonal Antibody ICA-1" Immunology of Diabetes 10th International Workshop Jerusalem, Israel, Mar. 18-24, p. 9 (abstract).
Pietropaolo, M. et al. (1992) "Molecular Cloning and Characterization of a Novel Neuroendocrine Autoantigen (PM-1) Related to Type I Diabetes" Diabetes 41(supp. 1):98A (abstract #356).
Pietropaolo, M. et al., (1991) "Utilization of a human Agtil islet library to identify novel autoantigens associated with Type I Diabetes" Diabetes 40:1A (abstract #2).
Pietropaolo et al. (1993) "Islet Cell Autoantigen 69 kD (ICA69) Molecular Cloning and Characterization of a Novel Diabetes-associated Autoantigen" J. Clin. Invest. 92(1):359-371.
Srikanta et al. (1986) "Islet Cell Proteins Defined by Monoclonal Islet Cell Antibody HISL-19" Diabetes 35:300-305.
Srikanta et al. (1986) Islet Cell Antigens Initial Studies of Their Biology and Function Molecular Biol. and Med. 3:113-127.
Tanguay et al. (1990) "A Cytotoxic Monoclonal Autoantibody From the BB Rat Which Binds An Islet Cell Surface Protein" Diabetes Research and Clinical Practice 8:23-28.
Roitt et al, "Immunology" Harper & Row, N.Y. 1987. pp. G1-G3.
Hirayama et al., Biochemical and Biophysical Research Communications, vol. 173, No. 2, Dec. 14, 1990, pp. 639-646, "Rapid Confirmation and Revision of the Primary Structure of Bovine Serum Albumin by Esims and Frit-Fab LC/MS".
Michelson et al., "Cloning, Characterization, and Autoimmune Recognition of Rat Islet Glutamic Acid Decarboxylase in Insulin-Dependent Diabetes Mellitus", Proceedings of the National Academy of the Sciences, vol. 88, Oct. 1991, pp. 8754-8758.
E. Houssaint et al., "Monoclonal Autoantibodies from Insulin-Dependent Diabetic Patients: Autoantibodies Against (Beta)-Cell Surface or Cytoplasmic Antigens", Clinical Experimental Immunology, vol. 82, Oct. 1990, pp. 44-51.
Pietropaolo, M. et al., Diabetes, (1991) vol. 40 (Abstract).
Srikanta et al., Molecular Biol. and Med., (1986) vol. 3:113-127.
Dotta et al., Endocrinology, (1988) vol. 122, No. 4, pp. 1263-1268.
Baekkeskov, S., et al., Nature, (Sep. 13, 1990)vol. 347:151-156.
Eisenbarth, G.S., New Eng. J. Medicine, (May 22, 1986) vol. 314:1360-1368.
Palmer, J.P., et al., Science, (Dec. 23, 1983) vol. 222:1337-1339.
Morein, Immunol.Letters, 25:281-284. 1990.
Hunkepiller et al, Methods in Enzymology, vol. 11. pp. 227-237. 1983.
Jaye et al, Nuc. Acid.Res. 11(8):2325-2335. 1983.
Srikanta et al, Diabetes 35:300-305. 1986.
Petrov et al, Biomedical Science 1:144-150. 1990.
Tanguey et al, Diabetes Res. & Clin. Practice, 8:23-28, 1990.
Pietropaolo et al. "Islet Cell Autoantigen 69 kD (ICA69)" J. Clin. Invest. 1993, vol. 92, No. 1, pp. 359-371.
Erlander et al. "Two Genes Encode Distinct Glutamate Decarboxylases" Neuron 1991 vol. 7, pp. 91-100.
Petrov R.V. et al. "Approaches to Immunodiagnostics IDDM Based on pp. 64-69 Beta-Cell Antigen Family and Corresponding Monoclonal Antibody ICA-1" Immunology of Diabetes 10th International Workshop Jerusalem, Israel, Mar. 18-24, 1990, p. 9.
Srikanta et al. "Islet Cell Proteins Defined by Monoclonal Islet Cell Antibody HISL-19" Diabetes 1986, vol. 35, pp. 300-305.
Eisenbarth George S.
Pietropaolo Massimo
Achutamurthy Ponnathapura
Wessendorf T. D.
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