Antigen arrays for treatment of allergic eosinophilic diseases

Details Antigen arrays for treatment of allergic eosinophilic diseases Antigen arrays for treatment of allergic eosinophilic diseases

2006-08-22

2006-08-22

Mosher, Mary E. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

C424S192100, C424S193100, C424S184100, C424S185100, C424S085200, C424S194100, C435S235100, C435S320100, C530S350000, C530S403000

Reexamination Certificate

active

07094409

ABSTRACT:
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

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