Multicellular living organisms and unmodified parts thereof and – Method of introducing a polynucleotide molecule into or... – The polynucleotide alters fat – fatty oil – ester-type wax – or...
Patent
1996-07-29
1998-10-20
Fox, David T.
Multicellular living organisms and unmodified parts thereof and
Method of introducing a polynucleotide molecule into or...
The polynucleotide alters fat, fatty oil, ester-type wax, or...
800250, 800255, 800DIG43, 800DIG44, 435 691, 435 701, 4351721, 4351723, 435423, 435425, 435418, 435419, 47 58, 47DIG1, 536 2374, A01H 500, C12N 504, C12N 582, C12N 1531
Patent
active
058248749
ABSTRACT:
The polypeptide with the sequence (SEQ ID NO:1)
Ala-Thr-Tyr-Asn-Gly-Lys-Cys-Tyr-Lys-Lys-Asp-Asn-Ile-Cys-Lys-Tyr-Lys-Ala-Gln -Ser-Gly-Lys-Thr-Ala-Ile-Cys-Lys-Cys-Tyr-Val-Lys-Lys-Cys-Pro-Arg-Asp-Gly-Al a-Lys-Cys-Glu-Phe-Asp-Ser-Tyr-Lys-Gly-Lys-Cys-Tyr-Cys
can be produced by the fermentation of Aspergillus giganteus and used as an antifungal agent.
Expression of this polypeptide gene in plants strongly inhibits the growth of phytopathogenic fungi on the plant.
REFERENCES:
patent: 3104204 (1963-09-01), Olson
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patent: 5049500 (1991-09-01), Arnizen et al.
patent: 5421839 (1995-06-01), Ulbrich et al.
Napoli et al. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. The Plant Cell. vol. 2 pp. 279-289, 1990.
Applied Microbiology, vol. 13, No. 3, May 1965, pp. 314-321; Olson, B.H. et al.: `Alpha sarcin, a new antitumor agent`.
Nuclic Acids Research, 18: 13 (1990) Arlington, VA US p. 3987, Wnendt et al.: `Cloning and nucleotide sequence of a cDNA encoding the antifungal-protein of Aspergillus giganteus and preliminary characterization of the native gene`.
J. Cell. Biochem. Suppl, vol. 14E, 1990, & Symposium Apr. 16-22, 1990, p. 268, Broglie, R., et al.: Chitinase expression in transgenic plants: increased protection against a soil-borne fungal pathogen.
Eur.J.Biochem, vol. 193, No. 1, 1990, pp. 31-38; Nakaya, K., et al.: `Amino acid sequence and disulfide bridges of an antifungal-protein isolated from Aspergillus giganteus`.
An et al., 1986, Plany Physicol. 81:301-305.
An et al., 1985, Plant Physicol 79:568-570.
Portrykus, 1991, Annu. Rev. Plant Physiol, Plant Mol. Bio. 42:205-225.
Weising et al., Ann Rev. Genet, 1988, 22:421-77 (Dec. 1988).
Braun Peter
Eckes Peter
Hanel Heinz
Hilgenfeld Rolf
Logemann Jurgen
Fox David T.
Hoechst Aktiengesellschaft
Kimball Melissa L.
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