Antifungal pastille formulation and method

Details Antifungal pastille formulation and method Antifungal pastille formulation and method

1984-05-24

1988-02-16

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424 78, 424 95, 514252, 514398, 514453, 514460, 514626, A61K 920, A61K 3512, A61K 3556, A61K 3174

Patent

active

047254408

ABSTRACT:
An antifungal pastille formulation, preferably containing nystatin as the antifungal agent, is provided which is soft and smooth in texture and when dissolved slowly in the mouth does not cause irritation of and will not adhere to oral mucosa and yet distributes nystatin in sufficiently high saliva concentrations, throughout the oral cavity, for long enough periods of time so as to be particularly effective in the treatment of candidiasis in the oral cavity and esophagus. A method for treating candidiasis in the oral cavity and esophagus employing the antifungal pastille and a method for preparing a nystatin pastille formulation are also provided.

REFERENCES:
patent: 2797183 (1952-01-01), Hazen et al.
patent: 2949401 (1960-08-01), Wershaw
patent: 3312594 (1967-04-01), Cyr et al.
patent: 4018918 (1977-04-01), Ayer et al.
Remington's Pharmaceutical Sciences, 15th Edition (1975), p. 1606.
Physician's Desk Reference, 26th Edition (1972), pp. 1338-1339.
Remington's Pharmaceutical Sciences, 16th Edition (1980), p. 1583.

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