Antifungal ketoconazole composition for topical use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S252100

Reexamination Certificate

active

07732450

ABSTRACT:
A pharmaceutical composition suitable for topical application comprising ketoconazole in a solution which comprises: (i) 13 to 50 wt % water; (ii) 45 to 85 wt % of an alcohol having a boiling point of less than 100° C.; and (iii) 2 to 30 wt % of a non-volatile, water miscible, non-ionic surface active agent; the ketoconazole being present in an amount of 0.5 to 3 st % relative to components (i), (ii) and (iii).

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patent: 6159479 (2000-12-01), Pinzon
Search Report , Feb. 8, 2001.
Salicylic Acid [online], 6 pgs. [retrieved from internet on Aug. 8, 2008 using URL <http://en.wikipedia.org/wiki/Salicylic—acid>].
Ketoconazole [online], 6 pgs. [retrieved from internet on Aug. 8, 2008 using URL <http://en.wikipedia.org/wiki/Ketoconazole>].
Ketoconazole (DB01026) [online], 18 pgs. [retrieved from internet on Aug. 8, 2008 using URL <http://www.drugbank.ca/cgi-bin/show—drug.cgi?CARD=APRD00401>].
Data From SRC PhysProp Database for CAS No. 065277-42-1 [online], 1 pg. [retrieved from internet on Aug. 8, 2008 via URL <http://www.drugbank.ca/cgi-bin/show—drug.cgi?CARD=APRD00401> at <http://esc.syrres.com/interkow/webprop.exe?CAS=65277-42-1>].
Ketoconazole MSDS [online], 6 pgs. [retrieved from internet on Aug. 8, 2008 via URL <http://www.drugbank.ca/cgi-bin/show—drug.cgi?CARD=APRD00401> at <http://www.drugbank.ca/public/files/drug—files/msds—sheets/DB01026.pdf].
XOLEGEL (Ketoconazole, USP) Gel FDA Label, [retrieved from internet on Aug. 8, 2008 via URL <http://www.drugbank.ca/cgi-bin/show—drug.cgi?CARD=APRD00401>at <http://www.drugbank.ca/public/files/drug—files/fda—labels/DB01026.pdf].

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