Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-12-21
1998-06-30
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 75, 536 168, A61K 3171, C07H 1500, C12P 1944
Patent
active
057734216
ABSTRACT:
Novel antifungal agents having the formula: ##STR1## wherein R is hydrogen or --C(O)--R.sub.1 wherein R.sub.1 is alkenyl, C.sub.2 -C.sub.12 -alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
REFERENCES:
patent: 4278665 (1981-07-01), Traxler et al.
patent: 5008187 (1991-04-01), Chavet et al.
patent: 5585251 (1996-12-01), Alder et al.
Hochlowski, J. E., et al., "Fusacandin A and B; Novel Antifungal Antibiotics of the Papulacandin Class from Fusarium sambucinum II. Isolation and Structural Elucidation", The Journal of Antibiotics, vol. 48, No. 7, Jul., 1995, pp. 614-618.
Komori, T., et al., Chaetiacandin, A Novel Papulacandin II. Structure Determination, The Journal of Antibiotics, vol. XXXVIII, NO. 4, Apr., 1995, pp. 544-546.
Traxler, P., et al., Papulacandins, A New Family of Antibiotics With Antifungal Activity / Structures of Papulacandins A, B, C and D, The Journal of Antibiotics, vol. XXXIII, No. 9, Sep., 1980, pp. 967-978.
Alder Lisa A.
Burres Neal S.
Hochlowski Jill E.
Jackson Marianna
Klein Larry L.
Abbott Laboratories
Anand Mona
Brainard Thomas D.
Peselev Elli
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