Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-nap

Details Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-nap Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-nap

1986-06-25

1988-06-14

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

2605011, 514554, 514645, 514649, 564300, 564387, 568448, 568841, 568842, 568843, 568873, A61K 31135, A61K 31205, C07C 8728, C07C12300

Patent

active

047512458

ABSTRACT:
N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine derivatives are provided having the general formula ##STR1## wherein R.sub.1 is methoxy, iminomethyl or 1-iminoethyl and R.sub.2 and R.sub.3 are each hydrogen; or R.sub.1 is methyl and one of R.sub.2 and R.sub.3 is hydrogen and the other is halogen.
The above compounds as well as acid-addition salts thereof are useful as antifungal agents.

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patent: 4382951 (1983-05-01), Grassberger et al.
Stutz et al., "Synthesis and Structure-Activity Relationships of Naftifine-Related Allylamine Antimycotics", J. Med. Chem., 1986, 29, pp. 112-125.
Stutz et al., "Synthesis and Antifungal Activity of (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine (SF 86-327) and Related Allylamine Derivatives with Enhanced Oral Activity", J. Med. Chem., 1984, 27, pp. 1539-1543.

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