Antifungal cyclohexapeptides

Details Antifungal cyclohexapeptides Antifungal cyclohexapeptides

1997-06-06

1998-12-29

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, A61K 3812, C07K 6764

Patent

active

058542132

ABSTRACT:
The present invention is directed to novel carba cyclohexapeptide compounds of the formula ##STR1## where all substituents are defined herein, which are useful as antifungal agents and for the treatment of Pneumocystis carinii infections. Compositions containing the compounds of the invention are also disclosed.

REFERENCES:
patent: 5166135 (1992-11-01), Schwatz
patent: 5194377 (1993-03-01), Schwartz et al.
patent: 5202309 (1993-04-01), Schwartz et al.
patent: 5378804 (1995-01-01), Balkovec et al.
patent: 5516756 (1996-05-01), Balkovec et al.
patent: 5516757 (1996-05-01), Balkovec et al.
Walzer, "Pneumocystis Carinii--New Clinical Spectrum . . ." NEJM; 324, No. 4, pp. 263-265, (Jan. 24, 1991).
Bartlett et al., "Pneumocystic Carinii, An Opportunists . . . " Clinical Microbiology Reviews; 4, No. 2, pp. 137-149, (Apr. 1991).
Schwartz et al., J. Antibiotics; 45 No. 12, pp. 1853-1866 (1992).
Walzer, et al., Diagn. Microbiol. Infect. Dis; 21, pp. 1-6 (1984).

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