Antifungal bifunctional molecules, methods of construction...

Details Antifungal bifunctional molecules, methods of construction... Antifungal bifunctional molecules, methods of construction...

2011-03-29

2011-03-29

Robinson, Hope A (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S300000, C435S252000, C435S325000, C435S007100

Reexamination Certificate

active

07915382

ABSTRACT:
The present invention is directed to fusion peptides comprising a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia, as well as the polynucleotides encoding the peptides of the invention. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms.

REFERENCES:
patent: 2003/0078207 (2003-04-01), Qiu
patent: 2003/0113293 (2003-06-01), Bermudes et al.
Mankovich et al. (Bacteriology, vol. 168, pp. 228-236, 1986).

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