Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-01-04
2011-01-04
Andres, Janet L. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C417S432000
Reexamination Certificate
active
07863465
ABSTRACT:
The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
REFERENCES:
patent: 5756472 (1998-05-01), Liesch et al.
patent: WO-97/27860 (1997-08-01), None
J. Onishi et al., Discovery of Novel Antifungal (1,3)-beta-D-Glycan Synthase Inhibitors, 44(2) Antimicrobial Agents & Chemotherapy, pp. 368-377 (Feb. 2000).
Fernando Pelaez et al., The Discovery of Enfumafungin, A Novel Antifungal Compound Produced by an Endophytic Hormonema Species Biological Activity and Taxonomy of the Producing Organisms, 23(3) Systemic & Applied Microbiology, pp. 333-343 (2000).
Robert E. Schwartz, et al., Isolation and Structural Determination of Enfumafungin, a Triterpene Glycoside Antifungal Agent That Is a Specific Inhibitor of Glucan Synthesis, 122 J. Am. Chem. Soc., pp. 4882-4886 (2000).
Ali Shafiee et al., Enzymatic Deglycosylation of Enfumafungin, a Triterpene Glycoside Natural Product, and its Chemically Synthesized Analogues, Journal of Molecular Catalysis B: Enzymatic 16, pp. 27-32 (2001).
Robert E. Schwartz, Cell Wall Active Antifungal Agents, 11(11) Expert Opinion on Therapeutic Patents, pp. 1761-1772 (2001).
Balkovec James M.
Bouffard Frances Aileen
Dropinski James
Fan Weiming
Greenlee Mark L.
Andres Janet L.
Berman Paul J.
Covington Raymond
Covington & Burling LLP
Merck Sharp & Dohme Corp.
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