Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-16
1999-03-16
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514462, A61K 31335, A61K 3134
Patent
active
058831207
ABSTRACT:
This invention relates generally to the field of antifungal agents and a pharmaceutical preparation containing those agents which appear to be potentially useful in the field of antifungal therapy. More particularly, this invention relates to the discovery of remarkably unexpected properties for a series of macrocyclic lactone polyethers (spongistatins) which are derived from the marine sponges Spongia sp. and Spirastrella spinispirulifera and which inhibited growth of yeasts and filamentous fungi in disk diffusion and broth macrodilution (for spongistatin 1) assays. Spongistatins 2-7 likewise demonstrated antifungal activity in disk diffusion methods. Therapeutic dosage forms are also described for the treatment of infections caused by Candida Albicans, Cryptococcus neoformans, Candida lusitaniae, Candida parapsilosis, Candida tropicalis, Candida glabrata, Issatchenkia orientalis, Rhodotorula mucilaginosa, Aspergillus fumigatus, Rhizopus ologosporus, and other yeast and filamentous fungi including strains resistant to amphotericin B, ketoconazole and flucytosine.
REFERENCES:
patent: 5328929 (1994-07-01), Pettit et al.
patent: 5393897 (1995-02-01), Pettit et al.
patent: 5436400 (1995-07-01), Pettit et al.
Arizona Board of Regents, a body corporate, acting on behalf of
Henley III Raymond
Mybeck Richard R.
Scull Peter B.
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