Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2001-12-11
2004-02-03
Navarro, Mark (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388200, C530S388400
Reexamination Certificate
active
06686453
ABSTRACT:
TECHNICAL FIELD
The present invention relates to an antibody that recognizes the structure of a physiologically active polysaccharide, fucoidan, which is useful for the functional study and the structural analysis of fucoidan.
BACKGROUND ART
Fucoidan is a polysaccharide that contains sulfated fucose in its molecule. Fucoidan that contains substantially no uronic acid and contains fucose as the main component of its constituting saccharides, and fucoidan that contains uronic acid and contains fucose and mannose as its constituting saccharides are known.
The present inventors prepared fucoidan that contains substantially no uronic acid and contains fucose as the main component of its constituting saccharides, i.e., sulfated-fucose-containing polysaccharide-F (hereinafter referred to as F-fucoidan), and fucoidan that contains uronic acid, i.e., sulfated-fucose-containing polysaccharide-U (hereinafter referred to as U-fucoidan) from
Kjellmaniella crassifolia
(see WO 97/26896).
Known physiological activities of fucoidan include an apoptosis-inducing activity, an antiproliferation activity against cancer, an activity of inhibiting cancer metastasis, an anticoagulant activity and an antiviral activity. Therefore, it is expected that fucoidan would be developed for medical use. In addition, fucoidan has an excellent function as a material for cosmetics.
Thus, it is desired to further analyze the structure and the physiological functions of fucoidan.
OBJECTS OF THE INVENTION
The main object of the present invention is to provide an antibody that specifically recognizes the structure of fucoidan, which antibody is useful for the structural analysis of fucoidan and the investigation of relationship between the structure and the physiological functions.
SUMMARY OF THE INVENTION
The present inventors have successfully created cells that produce antibodies that recognize the structure of fucoidan by immunizing a host with fucoidan derived from
Kjellmaniella crassifolia
as an antigen. Thus, the present invention has been completed.
Accordingly, the present invention provides an anti-fucoidan antibody that recognizes the compound of formula (I) or (II):
Furthermore, the present invention provides a carrier onto which said anti-fucoidan antibody is immobilized.
REFERENCES:
patent: 0 870 771 (1998-10-01), None
patent: 0 919 237 (1999-06-01), None
patent: 10-165184 (1998-06-01), None
patent: 87/04186 (1987-07-01), None
patent: 99/41288 (1999-08-01), None
Hino Fumitsugu
Kato Ikunoshin
Nakagawa Kazuo
Browdy and Neimark
Navarro Mark
Takara Shuzo Co. Ltd.
LandOfFree
Antifucoidan antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antifucoidan antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antifucoidan antibody will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3327332