Antiestrogens, process for their production and their pharmaceut

Details Antiestrogens, process for their production and their pharmaceut Antiestrogens, process for their production and their pharmaceut

1999-06-09

2000-12-26

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514724, 514718, 514727, 514708, 514709, 549545, 560254, 568633, 568 27, 568707, 568715, 568 28, A61K 3122, A61K 31045, A61K 31075, A61K 3110, C07D30300

Patent

active

061660752

ABSTRACT:
This invention relates to new antiestrogens of the general formula ##STR1## in which the substituents have the meanings that are explained in more detail in the description.
The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens).
Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.

REFERENCES:
J. Lu, et al., "Antioestrogenic activity of two 11beta-oestradiol derivatives on MCF-7 breast cancer cells" Steroids: Structure, Function and Regulation, Bd. 60, Nr. 8, Aug. 1, 1995, Seiten 512-518.
Aumann et. al., Steroid-Like Ring Skeletons by Cyclohexadiene Annulation to Enamines with Alkynylcarbene Complexes of Chromium and Tungsten via Pyran-2-ylidene Complexes, J. Am. Chem. Soc., 118, p. 10853-10861, 1996.

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