Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-10-12
1988-03-08
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514317, 514408, 514569, 514646, 514731, 514899, A61K 31535, A61K 31445, A61K 3140, A61K 3119
Patent
active
047299991
ABSTRACT:
The invention involves a method for treating symptoms secondary to estrogen deficiency without using estrogen. Weakly estrogenic antiestrogens are administered to estrogen deficient women in the absence of estrogen administration. Maximum estrogenic activity is therby obtained and the harmful side effects of estrogen therapy are avoided.
REFERENCES:
patent: 2914562 (1959-10-01), Allen
patent: 2914563 (1959-10-01), Allen
patent: 2914564 (1959-10-01), Allen
patent: 3634517 (1972-01-01), Palopoll et al.
patent: 3697581 (1972-10-01), Humber
patent: 3843727 (1974-10-01), Humber
patent: 4061733 (1977-12-01), Gurjikar
C. Hammond, M.D. et al., "Current Status of Estrogen Therapy for the Menopause," Fertil. Steril. 37(1):5-25 (1982).
J. Gallagher, et al., "Epidemiology of Fractures of the Proximal Femur in Rochester, Minnesota," Clin. Ortho. 150:163-171 (1980).
Boston Collab. Drug Surv. Program, "Surgically Confirmed Gallbladder Disease, Venous Thromboembolism, and Breast Tumors in Relation to Postmenopausal Estrogen Therapy," N. Eng. J. Med. 290(1):15-19 (1974).
M. Crane, M.D., et al., "Hypertension Oral Contraceptive Agents, and Conjugated Estrogens," Ann. Int. Med. 74(1):13-21 (1971).
R. Pfeffer, "Estrogen Use, Hypertension and Stroke in Postmenopausal Women," J. Chron. Dis. 31:389-398 (1978).
M. Notelovitz, "Metabolic Effect of Conjugated Oestrogens (USP) on Glucose Tolerance," So. African Med. J. 48(4):2599-2603 (1974).
J. Stangel, et al., "The Effect of Conjugated Estrogens on Coagulability in Menopausal Women," Obstet. Gynecol. 49(3):314-316 (1977).
T. Gordon, et al., "Menopause and Coronary Heart Disease," Ann. Int. Med. 89(2):157-161 (1978).
A. Kauppila, et al., "Comparison of Megestrol Acetate and Clomiphene Citrate as Supplemental Medication in Postmenopausal Oestrogen Replacement Therapy," Arch. Gynecol. 234:49-58 (1983).
A. Kaupilla, M.D., et al., "Postmenopausal Hormone Replacement Therapy with Estrogen Periodically Supplmented with Antiestrogen," Am. J. Obstet. Gynecol. 140(7):787-792 (1981).
A. Wise, et al., "Quantitative Relationships of the Pituitary-Gonadal Axis in Postmenopausal Women," J. Lab. Clin. Med. 81(1):28-36 (1973).
E. Su-Rong Huang, et al., "Estrogenic and Antiestrogenic Effects of Enclomiphene and Zuclomiphene on Gonadotropin Secretion by Ovine Pituitary Cells in Culture," Endocrinol. 112(2):442-448 (1983).
A. Mukku, et al., "Stimulatory and Inhibitory Effects of Estrogen and Antiestrogen on Uterine Cell Division," Endocrinol. 109(4):1005-1010 (1981).
M. Sankaran and M. Prasad, "A Critique on the Evaluation and Mode of Action of Antiestrogens," Horomones and Antagonists. Gynec. Invest. 3:143-147 (1972).
L. Terenius, et al., "Aspects on the Mode of Action of Antiestrogens and Antiprogestogens," Horomones and Antagonists. Gynec. Invest. 3:96-107 (1972).
C. Geynet, et al., "Estrogens and Antiestrogens," Hormones and Antagonists. Gynec. Invest. 3:2-29 (1972).
J. Wood, et al., "Estrogenic and Antiestrogenic Effects of Clomiphene, MER-25 and CN-55,945-27 on the Rat Uterine and Vagina," Endocrinol. 82:69-74 (1968).
K. Schulz, et al., "Studies on Anti-Oestrogenic and Oestrogen-Like Action of Clomiphene Citrate--Animal Experiments," Hormones and Antagonists. Gynec. Invest. 3:135-141 (1972).
J. Clark, et al., "The Agonistic-Antagonistic Properties of Clomiphene: A Review," Pharmac. Ther. 15:467-519 (1982).
M. Pugeat, et al., "On the Testing the Treshold of Sensitivity of the Gonadostat in the Late Menopausal Period: Effect of the Administration of Clomiphene Citrate or Ethynylestradiol on Plasma Levels of Gonadotropin, Testosterone and Delta-4 Antostendione," Eur. J. Obstet. Gynecol. Reprod. Biol. 9(3):218-219 (1979).
M. Zambrano, et al., "Evaluation of the Action of Clomiphene Citrate (Clomid) on Mouse Chromosomes by the Metaphase and Micronucleus Tests," Rev. Brasil. Genet. 2:339-344 (1982).
J. Gennes, et al., "Clinical, Biological, Histological and Genetic Studies of De Morsier's Syndrome (Hypogonadotrophic Hypogonadism with Anosmia)," Ann. Endocrinol. 31(5):841-861 (1970).
I. Spitz, et al., "The Decreased Basal and Stimulated Prolactin Levels in Isolated Gonadotrophin [sic] Deficiency: A Consequence of the Low Oestrogen State," Clin. Endocrinol. 16:423-432 (1982).
S. Aksel, M.D., et al., "Etiology and Treatment of Dysfunctional Uterine Bleeding," J. Obstet. and Gynec. 44(1):1--13 (1974).
T. Hashimoto, M.D., et al., "Endocrinological Study of Patients with Meningitis Tuberculosa," Jap. J. Med. 20(1):45-49 (1981).
C. March, M.D., "Effect of Pretreatment with Clomiphene Citrate Upon Human Menopausal Gonadotropin Therapy for Anovulation," Fertil. Steril. 26(2):191-192 (1975).
T. Hashimoto, M.D., et al., "Dual Effect of Clomiphene Citrate on Pituitary Gonadotropin Secretion in Postmenopausal Women," Endocrinol. Jap. 23(2):115-118 (1976).
T. Nencioni, et al., "Plasma FSH, LH and Prolactin Levels in Postmenopausal Women Undergoing Cyclofenil [sic] Treatment," Acta Obstet. Gynecol. Scand. 61:487-490 (1982).
R. Young, et al., "Antiestrogen Effects on Gonadotropins and Uterus in the Ovariectomized Rat," Abstracts of the Endocrine Society #142, p. 108 (1979).
M. Pugeat, et al., "Effects of Clomiphene and Estrogens on Circulating Gonadotropins, Testosterone, Androstenedione, in Old Menopausal Women," Ann. Endocrinol. 38:363-365 (1977).
A. LeBlanc, et al., "Effects of Clomiphene on Total Body Calcium in Aged Oophorectomized Rats," Calcium, Calcium Hormones, Abstract #7738, p. 1594 (1982).
H. Kupperman, et al., "Comparative Clinical Evaluation of Estrogenic Preparations by the Menopausal and Amenorrheal Indices," J. Clin. Endo. 13:688-703 (1953).
BCM Technologies
Brown J. R.
Mirabel Eric P.
Rollins Jr. John W.
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