Antidote for hirudin and synthetic thrombin inhibitors and metho

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 941, 424542, A61K 3847

Patent

active

058173099

ABSTRACT:
The invention relates to an antidote for hirudin and synthetic thrombin inhibitors; the antidote contains a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents. The present invention also relates to the application of a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, or a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents as an antidote for hirudin and synthetic thrombin inhibitors or for the preparation of an antidote for hirudin and synthetic thrombin inhibitors.

REFERENCES:
patent: 3849252 (1974-11-01), Percs et al.
patent: 4849403 (1989-07-01), Stocker et al.
patent: 5182260 (1993-01-01), Maraganore et al.
patent: 5187102 (1993-02-01), Stocker et al.
patent: 5196403 (1993-03-01), Maraganore et al.
patent: 5242810 (1993-09-01), Maraganore et al.
patent: 5547850 (1996-08-01), Nowak et al.
Stocker, Seminars in Thrombon's J. Hemostasis, vol. 17, No. 2, pp. 113-121, 1991.
Teng et al., Biochim. et Biophy. Acta, vol. 841, pp. 8-14, 1985.
Kornalik, F. et al., "Thrombosis and Hemostasis," vol. 50, #1, 1986, p. 267. Abstract #0837.
Merita, T. et al, "Biochem. (Japan)," vol. 79, #5, May 1976. pp. 1089-1108.
Gullin, M.C., et al, "Biochimica et Biophysisc Acta," vol. 537,#1, 1978, pp. 160-168.
Weller, T. et al, "Drugs of the Future," vol. 19, #5, 1994, pp. 461-476.
Moo-Jhong Rhee et al,; Biochemistry 1982, 21, 3437-3443.
Helene Hofmann, Cassian Bon; Biochemistry 1987, 26, 772-780.
Chemical Abstracts 90 (1979): 82920v; M.C. Guillin et al.; Biochim. Biophys. acta, 1978, 537 (1), 160-168.
Medline: 86225810; R.C. Schaeffer Jr. et al.; Lab. Clin. Med. 1986, 107 (6), 488-497.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antidote for hirudin and synthetic thrombin inhibitors and metho does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antidote for hirudin and synthetic thrombin inhibitors and metho, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antidote for hirudin and synthetic thrombin inhibitors and metho will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-74433

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.