Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1996-08-09
1998-10-06
Sayala, Chhaya D.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 941, 424542, A61K 3847
Patent
active
058173099
ABSTRACT:
The invention relates to an antidote for hirudin and synthetic thrombin inhibitors; the antidote contains a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents. The present invention also relates to the application of a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, or a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents as an antidote for hirudin and synthetic thrombin inhibitors or for the preparation of an antidote for hirudin and synthetic thrombin inhibitors.
REFERENCES:
patent: 3849252 (1974-11-01), Percs et al.
patent: 4849403 (1989-07-01), Stocker et al.
patent: 5182260 (1993-01-01), Maraganore et al.
patent: 5187102 (1993-02-01), Stocker et al.
patent: 5196403 (1993-03-01), Maraganore et al.
patent: 5242810 (1993-09-01), Maraganore et al.
patent: 5547850 (1996-08-01), Nowak et al.
Stocker, Seminars in Thrombon's J. Hemostasis, vol. 17, No. 2, pp. 113-121, 1991.
Teng et al., Biochim. et Biophy. Acta, vol. 841, pp. 8-14, 1985.
Kornalik, F. et al., "Thrombosis and Hemostasis," vol. 50, #1, 1986, p. 267. Abstract #0837.
Merita, T. et al, "Biochem. (Japan)," vol. 79, #5, May 1976. pp. 1089-1108.
Gullin, M.C., et al, "Biochimica et Biophysisc Acta," vol. 537,#1, 1978, pp. 160-168.
Weller, T. et al, "Drugs of the Future," vol. 19, #5, 1994, pp. 461-476.
Moo-Jhong Rhee et al,; Biochemistry 1982, 21, 3437-3443.
Helene Hofmann, Cassian Bon; Biochemistry 1987, 26, 772-780.
Chemical Abstracts 90 (1979): 82920v; M.C. Guillin et al.; Biochim. Biophys. acta, 1978, 537 (1), 160-168.
Medline: 86225810; R.C. Schaeffer Jr. et al.; Lab. Clin. Med. 1986, 107 (6), 488-497.
Bucha Elke
Nowak Gotz
Max-Planck-Gesellschaft
Sayala Chhaya D.
LandOfFree
Antidote for hirudin and synthetic thrombin inhibitors and metho does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antidote for hirudin and synthetic thrombin inhibitors and metho, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antidote for hirudin and synthetic thrombin inhibitors and metho will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-74433