Antidigoxin antibodies

Details Antidigoxin antibodies Antidigoxin antibodies

1985-09-10

1988-08-30

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

436531, 436545, 436546, 436817, 436823, G01N 33534, G01N 33566

Patent

active

047677201

ABSTRACT:
A digoxin derivative/immunogenic protein conjugate is disclosed which has the carbohydrate moiety of digoxin intact. Antibodies raised against this conjugate show minimal cross-reactivity to digoxin metabolites enabling the use as an antibody in the diagnostic analysis for digoxin when measured in the presence of its metabolites found in serum isolated from a human.

REFERENCES:
patent: 4469797 (1984-09-01), Albarella
Cerceo et al, "Factors Affecting the Radioimmunoassay of Digoxin," Clinical Chemistry, vol. 18, No. 6, pp. 539-542 (1972).
Lingwood, "Production of Glycolipid Affinity Matrices by Use of Heterobifunctional Crosslinking Agents," Journal of Lipid Research, vol. 25, pp. 1010-1012 (1984).
Butler et al, "Digoxin-Specific Antibodies," Proc. of Nat'l. Acad. Sciences, USA, vol. 57, pp. 71-78 (1967).
Soldin et al, "Are Immunoassays for Digoxin Reliable!", Clinical Biochemistry, vol. 17, pp. 317-320 (1984).
Deffo et al, "Photoaffinity Labeling of the Sodium- and Potassium-Activated Adenosinetriphosphatase with a Cardiac Blycoside Containing the Photoactive Group on the C-17 Side Chain," Biochemistry, vol. 22, pp. 6303-6309 (1983).
"Digoxin Derivatives", Chem. Abst. 103: 54404y, p. 612, Aug. 19, 1985.
"Digoxin Derivatives", Chem. Abst. 104, 69120x, p. 71, 1986.

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