Antidiabetic spiro-3-heteroazolidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514228, 514231, 514234, 514253, 514278, 514369, 514382, 544 70, 544230, 546 15, 548147, 548253, 548309, A61K 31415, C07D491107

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active

047405171

ABSTRACT:
A spiro-3-heteroazolidine compound and agents comprising that compound which have special utility as an antidiabetic composition and as a substance to inhibit aldose reductase enzyme activity.

REFERENCES:
patent: 4540704 (1985-09-01), Ueda et al.
Kinoshita, J., et al., Jap. J. Opthalmol., vol. 20, pp. 399-410 (1976).
Gabbay, K., Int. Congr. Ser. Excerpta. Med., vol. 403, pp. 594-598 (1977).
Peterson, M., et al., Metabolism, vol. 28, pp. 456-461 (1979).
CA, vol. 69, 2798q (1968) [Canalini, G., et al., Ann. Chim. 1967, 57(10), 1045-72].
CA, vol. 70, 47334x (1969) [Fravolini, A., et al., Ann. Chim. 1968, 58(10), 1155-62].
Kabbe, M. Synthesis, pp. 886-887 (1978).

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