Antidiabetic phosphonates

Details Antidiabetic phosphonates Antidiabetic phosphonates

1988-08-12

1990-07-31

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 25, C07H 1104

Patent

active

049451588

ABSTRACT:
Phosphonates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These phosphonates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the phosphonates are also disclosed.

REFERENCES:
patent: 4745185 (1988-05-01), Maryanoff et al.
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Nicotra et al., J. Org. Chem., 52, 5627-5630 (1987).
Reitz et al., Tetrahedron Letters, 26, 3915-3918 (1985).
Maryanoff et al., Carbohydrate Res., 171, 295.278 (1987).
Hanson et al., The Journal of Biological Chemistry, Inhibition of Gluconeogenesis and Glycogenolysis by 2,5-Anhydro-D-Mannitol, vol. 259, No. 1, Jan. 10, pp. 218-223, 1984.
The British Drug Houses Ltd., "Sugar Phosphates and Some Closely Related Substances", Mar. 1958, p. 5.

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