Antidiabetic oxazolidinediones and thiazolidinediones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S314000, C514S376000, C514S340000, C546S271400, C546S166000, C548S227000

Reexamination Certificate

active

07807692

ABSTRACT:
Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

REFERENCES:
patent: 6784184 (2004-08-01), Epstein et al.
patent: 2007/0173434 (2007-07-01), Shi et al.
patent: 1 709 014 (2006-10-01), None
patent: 99/32465 (1999-07-01), None
patent: WO 01/30343 (2001-05-01), None
patent: WO 02/08188 (2002-01-01), None
patent: WO 2005/007095 (2005-01-01), None
Hcaplus Abstract 138:221580, “Preparation of arylsulfonylthiazolidinediones as inhibitors of farnesyl-protein transferase”, Salaski et. al., 2003.
H. K. Rami et al., “Synthetic ligands for PPAR gamma—review of patent literature 1994-1999”, Expert Opinion on Therapeutic Patents, vol. 10, No. 5, pp. 623-634 (2000).

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