Antidiabetic alpha-substituted phosphonates

Details Antidiabetic alpha-substituted phosphonates Antidiabetic alpha-substituted phosphonates

1988-08-12

1990-07-24

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1104

Patent

active

049436295

ABSTRACT:
Alpha-substituted phosphonates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These alpha-substituted phosphonates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the alpha-substituted phosphonates are also disclosed.

REFERENCES:
patent: 4745185 (1988-05-01), Maryanoff et al.
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Reitz et al., Tetrahedron Letters, 26, 3915-3918 (1985).
Maryanoff et al., Carbohydrate Res., 171, 259-278 (1987).
Hanson et al., Inhibition of Gluconeogenesis and Glycogenolysis by 2,5-Anhydro-D-Mannitol, vol. 259, No. 1, Jan. 10, pp. 218-223, 1984.

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