Antidiabetic agent for control of diabetic hyperglycemia and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S039000

Reexamination Certificate

active

07973073

ABSTRACT:
Described herein is a compound of Formula I, which is the metformin salt of the naturally occurring endogenous biological compound, (R)-(+) α lipoic acid, pharmaceutical compositions containing the compound of Formula I, and methods of treatment of diabetes or diabetic complications with the compound of Formula I.

REFERENCES:
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patent: 2001/0028896 (2001-10-01), Byrd
patent: 2003/0078269 (2003-04-01), Pearson et al.
patent: 2003/0220301 (2003-11-01), Lal et al.
patent: 2003/0228362 (2003-12-01), Byrd
patent: 2005/0182029 (2005-08-01), Lal
patent: 2 796 551 (2001-01-01), None
patent: WO-99/61004 (1999-12-01), None
patent: WO-03/068209 (2003-08-01), None
patent: WO-2005/039539 (2005-05-01), None
International Search Report from PCT/US2007/014034, mailed Dec. 3, 2007.
Carlson et al., “The Plasma Pharmacokinetics of R-(+)-Lipoate to Healthy Human Subjects”,Alternative Medicine Review, 12:(4)343-351 (2007).

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