Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-

Details Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro- Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-

1980-09-05

1985-12-03

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

260465E, 2605011, 560 57, 560101, 562468, 562491, 564272, 564304, 564308, 568326, 514555, 514647, A61K 31135, A61K 31205, C07C 8764

Patent

active

045566763

ABSTRACT:
Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.

REFERENCES:
patent: 3704323 (1972-11-01), Krapcho
patent: 4045488 (1977-08-01), Sarges
Burger, "Medicinal Chemistry", 3rd Ed., Part II, pp. 1470, 1473-1475, 1478-1479 and 1489-1493, (1970).
Koe, "The Jour. Pharmacology and Experimental Therapeutics", vol. 199, No. 3, pp. 649-661, (1976).

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