Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-

Details Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1- Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-

1979-11-01

1985-08-20

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514555, 564308, A01N 3302, C07C 8764

Patent

active

045365180

ABSTRACT:
Novel cis-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnormalities at central receptor sites. The preferred embodiment is the enantiomer cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenam ine and its pharmaceutically acceptable acid addition salts.

REFERENCES:
patent: 2887509 (1959-05-01), Nash
patent: 3704323 (1972-11-01), Krapcho
patent: 4029731 (1977-06-01), Sarges
Burger, "Medicinal Chemistry", 3rd ed., Part II, pp. 1470, 1473-1475, 1478-1479, 1489, and 1490-1493, (1970).
Koe, B. K., "Molecular Geometry of Inhibitors of the Uptake of Catecholamines and Serotonin in Synaptosomal Preparations of Rat Brain", Jour. Pharmac. and Exper. Ther., 199(3), pp. 649 to 661, (1976).

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