Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-12-26
2006-12-26
Richter, Johann (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S253030, C540S575000, C544S361000
Reexamination Certificate
active
07153849
ABSTRACT:
Compounds of the formula I:are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
REFERENCES:
patent: 5869490 (1999-02-01), Stack
patent: 91/13872 (1991-09-01), None
patent: 98/16530 (1998-04-01), None
Robichaud et al. Annual Reports in Medicinal Chemistry, vol. 35, p. 11-20 (2000).
Artigas, F., et al., “Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors,”Arch Gen Psychiatry,Mar. 1994, 51, 248-251.
Blier, P., et al., “Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression,”J. of Clinical Psychopharmacology,1995, 15(3), 217-222.
Bundgaard, H., “Means to enhance penetration; Prodrugs as a means to improve the delivery of peptide drugs,”Advanced Drug Deliver Reviews,1992, 8, 1-38.
Hall, M.D., et al., “{3H]8-hydroxy-2-(Di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain,”J. Neurochem.,1985, 44, 1685-1696.
Krogsgaard-Larsen, et al. (Eds.), “Design and Application of Prodrugs,”Texbook of Drug Design and Development,1991,Chap. 5,113-123.
Lazareno, S., et al., “Pharmacological characterization of acetylcholine-stimulated [3S]-GTPγS binding mediated by human muscarinic m1-m4 receptors: antagonist studies,”Br. J. Pharmacol.,1993, 109, 1120-1127.
Ostrowski, S., “A synthesis of fused pyrimidine mono-n-oxides,” Heterocycles, 1996, 43(2), p. 389-396.
Perez, V., et al., “Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment,”The Lancet,m May 31, 1997, 349, 1594-1597.
Tome, M.B., et al., “Serotonergic autoreceptor blocade in the reduction of antidepressant latency: personality variables and response to paroxetine and pindolol,”J. Affect Disord,1997, 44, 101-109.
Tome, M.B., et al., “Paroxetine and pindolol: a randomized trial of serotonergic antoreceptor blockade in the reduction of antidepressant latency,”Int. Clin. Psychopharmacol,1997, 12, 81-89.
Wilen, S.H., “Tables of Resolving Agents and Optical Resolutions,”Univ. of Notre Dame Press, Notre Dame, IN,E.L. Eliel (Ed.), 1972, p. 268-298.
Wilen, S.H., et al., “Strategies in optical resolutions,”Tetrahedron,1977, 33, 2725-2736.
Bundgaard, H. (ed.),Design of Prodrugs,Elsevier (1985), Ch. 1 (pp. 1-92), Ch. 4 (pp. 157-176), Ch. 5 (pp. 177-198), and Ch. 6 (pp. 199-241).
Bundgaard, H. et al., “Glycolamide Esters as Biolabile Prodrugs of Carboxylic Acid Agents: Synthesis, Stability, Bioconversion, and Physicochemical Properties,”J. of Pharmaceutical Sciences,Apr. 1988, 77(4):285-298.
Eliel, E. L.,Stereochemistry of Carbon Compounds,McGraw Hill, NY (1962) Ch. 4, pp. 46-87.
Higuchi and Stella (eds.),Prodrugs as Novel Drug Delivery Systems,American Chemical Society (1975), pp. 1-115 and 196-223.
Jacques, J. et al.,Enantiomers, Racemates and Resolutions,Wiley Interscience, NY (1981) pp. 251-434.
Remington's Pharmaceutical Sciences, 17thEd., Gennaro, A. R. (Ed.), Mack Publishing Company, Easton, PA (1985) pp. 1409-1677.
Widder, et al. (ed.),Methods in Enzymology,vol. 112, Academic Press (1985), pp. 309-396.
Croce Susan Christman
Evrard Deborah Ann
Failli Amedeo A.
Stack Gary Paul
Venkatesan Aranapakam Madumbai
Richter Johann
Sackey Ebenezer
Woodcock & Washburn LLP
Wyeth
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