Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-12-07
1986-07-22
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549304, 549467, 564316, 558388, 558408, A61K 3134, C07D30781
Patent
active
046020357
ABSTRACT:
There are described compounds of the formula ##STR1## where n is 2 or 3, X and Y are each independently hydrogen, loweralkyl, or halogen, and R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, cyano, beta,beta,beta-trichloroethyoxycarbonyl, cyclopropylmethyl, phenethyl, or cyanoethyl, but at least one of the two is loweralkyl, which are useful as antidepressant and analgesic agents; novel intermediate compounds for preparing said compounds; and methods for synthesizing the foregoing compounds.
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Weston et al., J. Am. Chem. Soc., vol. 74, pp. 653-656, (1952).
Petersen et al., Acta. Pharmacol. et Toxicol., vol. 24, pp. 121-133 (1966).
Burger's Medicinal Chem., 4th Ed. (Part III), Wiley and Sons, pp. 847-848 (1979).
Diamond Craig J.
Helsley Grover C.
Tegeler John J.
Dentz Bernard I.
Hoechst-Roussel Pharmaceuticals Inc.
Ikeda Tatsuya
Jiles Henry R.
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