Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-09-30
1986-09-23
Lesmes, George F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544366, C07D24900, A61K 3141
Patent
active
046136002
ABSTRACT:
2-[3-[4-(3-Halophenyl)-1-piperazinyl]propyl]-5-(1-hydroxyethyl)-2,4-dihydro -[4-phenoxyalkyl-3H-1,2,4-triazol-3-ones and closely related compounds are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology.
REFERENCES:
patent: 3381009 (1968-04-01), Palazzo et al.
patent: 3857845 (1974-12-01), Palazzo
patent: 4338317 (1982-07-01), Temple, Jr. et al.
La Selva, et al., Riv. Neuropsichiat. Sci. Affini., 25/2, 57-68 (1979).
Silvestrini, et al., International Journal of Neuropharmacology, 7, 587-599 (1968).
Fabre, et al., Current Therapeutic Research, 25, 827-834 (1979).
Temple, Jr., et al., U.S. Ser. No. 06/509,266 filed 6/29/83.
Gammans Richard E.
Smith David W.
Yevich Joseph P.
Gibson S. A.
Lesmes George F.
Mead Johnson & Company
Ryan Richard P.
Uloth Robert H.
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