Anticonvulsive and antiallergic/antiasthmatic pyrazolo-[3,4-d]py

Details Anticonvulsive and antiallergic/antiasthmatic pyrazolo-[3,4-d]py Anticonvulsive and antiallergic/antiasthmatic pyrazolo-[3,4-d]py

1999-06-15

2000-04-25

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544262, A61K 31519, C07D48704

Patent

active

060544600

ABSTRACT:
The invention relates to pyrazolo[3,4d]pyrimidin-4(5H)-ones and pyrazolo[3,4-d]pyrimidine-4(5H)-thiones and their tautomers and pharmaceutically acceptable salts, which contain a benzyl radical in the 2-position, processes for their preparation and their use as medicaments, in particular for the treatment of epilepsies of various forms and of allergic/asthmatic diseases.

REFERENCES:
Gatta, F. et al., "Pyrazolo [3,4-D]pyrimidines Related to Lonidamine", J. Heterocyclic Chem., vol. 26, pp 613, 1989.
El Hedi Jellali, M. et al., "Acylation and alkylation of 4-aminopyrazolo [3,4-d] Pyrimidine", Tetrahedron, vol. 31, pp 587, 1975.
Eisenacher, Th. et al., "Ueber Neue Pyrazolverbindungen: 6.Mitteilung: Pyrazolo [3,4-d] pyrimidinylessigsaurederivate", Pharmazie Bd. 46, Nr. 10, 1991.
Eisenaecher et al. New pyrazole compounds. Pharmazie 46(10), 747-8, 1991.

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