Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-09-21
1994-02-01
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544279, 544284, 544287, 544290, 544258, A61K 31505, C07D47104
Patent
active
052832473
ABSTRACT:
Disclosed herein are substituted quinazolones and their N.sup.1 -oxide derivatives, methods of synthesizing such compounds, and methods of using them to treat or prevent convulsions in mammals. The substituted quinazolones are represented by the formula: ##STR1## wherein X.sub.1 is N, S, O, or CH, X.sub.2 is N or CH, R.sub.1 and R.sub.2 are H, NO.sub.2, or NH.sub.2 except that when one of R.sub.1 and R.sub.2 is NO.sub.2 or NH.sub.2 the other is H, R.sub.3 and R.sub.4 are alkyl with 1-5 C atoms, and R.sub.5, R.sub.6, and R.sub.7 are H or halogen, provided that when X.sub.1 is N, S, or O, X.sub.2 is CH.
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Ibid, Chemical Abstract. vol. 77, 1972 #140121e.
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Karamchand Premchand, Chemical Abs., vol. 77, 1972 #126679m.
Karamchand Premchand, Chemical Abstract, vol. 77, 1972 #140121e.
Maruyama, et al., Chemical Abstract, vol. 77, 1972 #101653.
Maruyama, et al., Chemical Abstract, vol. 77, 1972 #101654.
Bhaduri et al., "Indian Journal of Chemistry" vol. 18B, pp. 443-448, 1979.
Dwivedi Chandradhar
Omodt Gary W.
Ford John M.
Gupta Y. N.
Research Corporation Technologies Inc.
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