Anticonvulsant N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas

Details Anticonvulsant N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas Anticonvulsant N-(2,6-disubstituted aromatic)-n'-pyridinyl ureas

1985-04-30

1986-12-16

Jiles, Henry H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546306, C07D21375, A61K 3144

Patent

active

046297316

ABSTRACT:
N-(2,6-Disubstitutedphenyl)-N'-3- and 4-pyridinyl ureas and pharmaceutically acceptable acid addition salts having anticonvulsant activity are described as well as a process for their manufacture, formulations containing the compounds and a method of treating epilepsy using the compounds in unit dosage form.

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Dorlands' Illustrated Medical Dictionary 26th Edition p. 1186.
Wilder, B. J. et al., "Valproate-Relation of Plasma Concentration to Seizure Control" from Antiepileptic Drugs edited by Woodbury, D. M. et al., (1982), pp. 591-599.
Wiley, J. "The Chemistry of Heterocyclic Compounds, 3rd Edition" pp. 257-261, (1976).
Richens, A. "Drug Treatment of Epilepsy" Henry Kimpton Publishers, London (1976) pp. 52-60.
The Merck Manual, 13th Edition (1977) pp. 1410-1411.
Swinyard, E. A. et al., "Antiepileptic Drug Development: II: Anticonvulsant Drug Screening" Epilepsia 19: 409-428, (1978).
Bruce, M. I. et al., "Cytokinin Activity of Some Substituted Ureas and Thioureas" Proc. Roy. Soc. (London) Sec. B, 165 (999), pp. 245-265, (1966).

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