Anticonvulsant fructopyranose cyclic sulfites and sulfates

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 23, 549 31, 549336, 549396, 536 54, A61K 3139, C07D49714

Patent

active

052429423

ABSTRACT:
Compounds of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n and p are as herein defined; exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Compounds of this class are also useful for the treatment of glaucoma, peptic ulcers, hypertension, congestive heart failure and other types of edema. Furthermore, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and novel intermediates are disclosed.

REFERENCES:
patent: 4075351 (1978-02-01), Hirsch
patent: 4513006 (1985-04-01), Maryanoff, II et al.
patent: 4591601 (1986-05-01), Maryanoff et al.
patent: 4792569 (1988-12-01), Maryanoff et al.
B. Maryanoff et al., (I), J. Med. Chem, 30 (5) pp. 880-887 (1987).

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