Anticonvulsant enantiomeric amino acid derivatives

Details Anticonvulsant enantiomeric amino acid derivatives Anticonvulsant enantiomeric amino acid derivatives

1997-03-17

1998-06-30

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564155, 564158, A61K 3116, A61K 31165, C07C23305

Patent

active

057734755

ABSTRACT:
The present invention is directed to a compound in the R configuration about the asymmetric carbon in the following formula: ##STR1## pharmaceutical compositions containing same and the use thereof in treating CNS disorders in animals.

REFERENCES:
patent: 5378729 (1995-01-01), Kohn et al.
patent: 5654301 (1997-08-01), Kohn et al.
Anderson et al, J.Am.Chem. Soc., 89:19, pp. 5012-5017, 1967.
Kohn, Harold et al. "Preparation and anticonvulsant activity of a series of functionalized. alph.-heteroatom-substituted amino acids", J. Med. Chem., 1991, 34, 2444-2452.
Kohn, Harold et al. "Marked stereospecificity in a new class of anticonvulsants", Chemical Abstracts, 1988, 109, Abstract No. 183045.
Choi, Daeock et al. "Synthesis and Anticonvulsant Activities of N-Benzyl-2-acetamidopropionamide Derivatives", J. Med. Chem., 1996, 39, 1907-1916.

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