Anticonvulsant dioxolane methane sulfamates

Details Anticonvulsant dioxolane methane sulfamates Anticonvulsant dioxolane methane sulfamates

1985-04-12

1986-05-27

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514467, 549333, 549451, 549453, A61K 31335, C07D31900, C07D31700

Patent

active

045916012

ABSTRACT:
Sulfamates of the following formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are as herein defined have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and intermediates form part of the present invention.

REFERENCES:
patent: 3058981 (1962-10-01), Avakian et al.
patent: 3246012 (1966-04-01), Feit
patent: 3948953 (1976-04-01), McCoy
patent: 4075351 (1978-02-01), Hirsch
N. K. Kochetkov et al. in Zhurnal Obshchei Khimii, vol. 41, No. 8, pp. 1874-1878, (1971).
N. K. Kochetkov et al. in Journal of General Chemistry of the USSR 42 (12) 2755-2757 (1972).
N. K. Kochetkov et al. in Journal of General Chemistry of the USSR 44 (4) 871-875 (1974).
N. K. Kochetkov et al. in Doklady Akademii Nauk SSSR, vol. 216, No. 1, pp. 97-100, (1974).
Tetrahedron Letters No. 36, pp. 3365-3368, Pergamon Press Ltd. (1978) by T. Tsuchiya.
J. Med. Chem. 1981, 24, 901-903, A. F. Hirsch.

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