Anticomplement activity assays

Details Anticomplement activity assays Anticomplement activity assays

1991-04-22

1999-10-26

Ceperley, Mary E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4241771, 435 75, 435337, 436545, 436804, 436821, 5303893, 5303905, G01N 3396, A61K 39395

Patent

active

059726326

ABSTRACT:
Immunoassays for complement components, complement activation products or, preferably both, can be used to determine an acceptable level of anticomplement activity (AC) in plasma derived biologically active products intended for infusion into a mammal. In one application an ELISA for complement components (CC) such as C1q, C1r or C1s can be used to determine AC in an IgM-enriched immune serum globulin (ISG). In another application, an immunoassay for complement activation products (CAP) is used for a similar determination. In yet a preferred third application, assays for both a CC (such as measuring a decreasing amount of C1r) and a CAP (such as measuring an increasing amount of C4a) are used to assess the relative AC (and safety) of a biologically active, therapeutic preparation.

REFERENCES:
Bing, Molecular Immunology, vol.20, No. 8, pp. 893-900, (1983).
Hassig, Vox Sang., vol. 51, pp. 10-17, (1986).
G. Tsay, The FASEB Journal, Abstract 2294, Apr. 26,1990.
A.K. Abbas et al, Cellular and Molecular Immunology, W. B. Saunders Co., Chap. 13, pp. 260-282, 1991.
J.L. Wagner et al, Anal. Biochem. 136, 75-88, 1984.
R.J. Ziccardi et al, Clin. Immunol. and Immuno Path, 15, 465-471, 1980.

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