Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-11-10
2002-05-07
Rotman, Alan L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S326000, C514S327000, C514S330000, C514S333000, C514S347000, C514S362000, C514S354000, C514S427000, C546S184000, C546S193000, C546S208000, C546S216000, C546S223000, C546S244000, C546S248000, C548S518000, C548S530000, C548S544000, C548S564000
Reexamination Certificate
active
06384052
ABSTRACT:
SUMMARY OF THE INVENTION
The present invention provides trisubstituted pyrroles as anticoccidial agents, their use in controlling coccidiosis, and compositions containing them.
BACKGROUND OF THE INVENTION
Coccidiosis is a widespread poultry disease which causes severe pathology in the intestines and ceca of poultry. It is produced by infections with protozoans of the genus Eimeria; some of the most significant of these species are
E. tenella, E. acervulina, E. mitis, E. necatrix, E. brunetti
, and,
E. maxima
. This disease is generally spread by the birds picking up the organism at its infectious stage in droppings on contaminated litter or ground, or by way of food or drinking water. The disease is manifested by hemorrhage, accumulation of blood in the ceca, passage of blood in the droppings, weakness and digestive disturbances. The disease often terminates in the death of the animal, but the fowl which survive severe infections have had their market value substantially reduced as a result of the infection. Coccidiosis is, therefore, a disease of great economic importance and extensive work has been done to find new and improved methods for controlling and treating coccidial infections in poultry.
In the poultry industry it is common practice to include anticoccidial agents in poultry feed for most of the bird's life to control or prevent coccidiosis outbreak. However, there is a risk that the causative organisms will develop resistance after continuous or repeated exposure to any particular drug. Furthermore, conventionally used anticoccidial agents such as sulfanilamides, nitrofurans, quinolines, antithiamines, benzoamides, and polyether-based antibiotics are often toxic to the hosts. Therefore, there is a continuing need to identify new anticoccidial compounds, preferably in a different chemical class from agents currently in use.
U.S. Pat. No. 5,792,778 discloses 2-substituted aryl pyrroles as useful for the treatment of diseases related to excessive cytokine production in mammals. The compound 2-(4-fluorophenyl)-5-(N-methylpiperidin-4-yl)-3-(4-pyridyl)pyrrole is specifically disclosed therein.
REFERENCES:
patent: 5792778 (1998-08-01), de Laszlo et al.
patent: WO 97/16426 (1997-05-01), None
patent: WO 97/48725 (1997-12-01), None
Chemical Abstract vol. 126 No. 225212, DeLaszlo et al, “Preparation of arylpyrroles as cytokine inhibitors” (1997).*
Lowenthal, et al., Database Medline on Stn, No. 97474409, Abstract, J. Interferon and Cytokine Res., vol. 17 (9), pp. 551-558, 1997.
Bitfu Tesfaye
Feng Danqing D.
Covington Raymond
Merck & Co. , Inc.
Rose David L.
Rotman Alan L.
Yang Mollie M.
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