Anticoagulant therapy

Details Anticoagulant therapy Anticoagulant therapy

1987-11-06

1989-12-05

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514802, 530328, 530330, 530800, A61K 3702, C07K 708

Patent

active

048852775

ABSTRACT:
A composition and method for treating thrombotic disorders. The composition comprises a peptide comprising an amino acid sequence corresponding to the sequence of the amino acid residues in the EGF domain of Factor IX, or a subsequence thereof. Such peptides compete with coagulation Factors IX and IXa for endothelial binding cites and thereby inhibit thrombosis formation.

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The EGF Domain of the Factor IX Molecule is Involved in Factor IX-Endothelial Cell Interaction, Nawroth et al., 59th Scientific Sessions, American Heart Association, Circulation 74, (Suppl. II):232, (Abstract No. 929), 1986.

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