Anticoagulant substance obtained from urine and process for the

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 514 8, 514 12, 530381, 530399, 530412, 530413, 530416, 530417, 530834, C07K 1514, C07K 318

Patent

active

052024210

ABSTRACT:
This invention relates to a novel glycoprotein with anticoagulant activity in human urine, a process for its preparation and a pharmaceutical composition comprising the said glycoprotein for the prevention and/or treatment of diseases related to the disorders in the blood coagulation system.

REFERENCES:
patent: 4845078 (1989-07-01), Magaoka
patent: 4873222 (1989-10-01), Arai et al.
patent: 5047503 (1991-09-01), Aoki et al.
Yoshikawa et al.; "Protection of Endotoxin-Induced Disseminated Intravascular Coagulation in Rats by Gabexate Mesilate"; Kyoto Profectural Univ. of Med.; pp. 633-640.
Ishii et al.; Yakugakkai Abstract 6F05, Nov. 1, 1988.
Ishii et al.; "Thrombomodulin is Present in Human Plasma and Urine"; J. Clin. Invest., vol. 76, Dec. 1985, pp. 2178-2181.
Palareti et al.; Thrombosis and Haemostasis; "Effects of Gabexate Mesilate, A New Synthetic Serine Protease Inhibitor on Blood Coagulation in Patients with DIC"; Jour. International Soc. on Thrombosis and Haemostasis; No. 1, vol. 58, 1987, p. 420.
Schoendorf et al.; "Endotoxin-Induced Disseminated Intravascular Coagulation in Nonpregnant Rats"; Dept. of OB/GYN.; NY Schol of Med; 1971; pp. 51-58.
Ng et al.; "Pasteurization of Antihemophilic Factor and Model Virus Inactivation Studies"; Thrombosis Research 39; 1985, pp. 439-447.
Zushi et al.; "The Last Three Consecutive Epidermal Growth Factor-Like Structures of Human Thrombomodulin Comprise the Minimum Functional Domain for Protein C-Activating Cofactor Activity and Anticoagulant Activity"; Jour. of Bio. Chem. vol. 264, No. 18, 1989, pp. 10351-10353.
Gomi et al.; "Minimum Functional Domain of Human Thrombomodulin for Protein C Activating Cofactor Activity and Anticoagulant Activity"; Jour. of the International Soc. on Thrombosis and Haemostasis; Thrombosis and Haemostasis; Abstract 1039; 1989; p. 334.
Maruyama et al.; "Human Thrombomodulin is not an Efficient Inhibitor of the Procoagulant Activity of Thrombin"; J. Clin. Invest.; vol. 75, 1985; pp. 987-991.
Salem et al.; "Isolation and Characterization of Thrombomodulin From Human Placenta"; Jour. Bio. Chem., 1984; vol. 259, No. 19, 1984; pp. 12246-12251.
Suzuki et al.; "Functionally Active Thrombomodulin is Present in Human Platelets"; J. Biochem, 104, 1988, pp. 628-632.
Robbins et al.; "Plasmin and Plasminogen Activators: Kinetics, and Kinetics of Plasminogen Activation"; Annals N.Y. Acad. of Sci., 1981; pp. 588-591.
Kurosawa et al.; "A 10-KDA Cyanogen Bromide Fragment from the Epidermal Growth Factor Homology Domain of Rabbit Thrombomodulin Contains the Primary Thrombin Binding Site"; Jour. Bio. Chem; vol. 263, No. 13, 1988, pp. 5993-5996.
Suzuki, K., et al., J. Bio. Chem., 264, 4872, 1989.
Rees, M. W., et al, Chemical Abstracts, 85, 490, Abstract No. 6027r, 1976.
Wen et al, Biochem. vol. 26 pp. 4350-4357 (1987).
Suzuki et al., EMBO Journal, vol. 6 (7) pp. 1891-1897 (1987).
Jackman et al., Proc. Nat. Acad. Sci. USA, vol. 84, pp. 6425-6429 (1987).
Shirai et al., "Gene Structure of Human Thrombomodulin, A Cofactor for Thrombin-Catalyzed Activation of Protein C"; J. Biochem., 103, 281, 1988.
Sottrup-Jenson, L. et al., "The Primary Structure of Human Plasminogen . . . "; Progress in Chemical Fibrinolysis and Thromobolysis, 3, 191, 1978.
Moroz, L. A., "Mini-Plasminogen: A Mechanism for Leukocyte Modulation of Plasminogen Activation by Urokinase"; Blood, 58, 97, 1978.
White, W. F. et al., "The Isolation and Characterization of Plasminogen Activators from Human Urine"; Biochemistry, 5, 2160, 1966.
Bernik, M. B. et al., "Production by Human Tissues in Culture of Immunologially Distinct, Multiple Molecular Weight Forms of Plasminogen Activators"; Annals New York Academy of Sciences; 593-608, 1981.
Joel L. Moake, Current Therapy, 1989, "Disseminated Intravascular Coagulation" pp. 338-339.
B. Blauhut et al., Thrombosis Research, 1985, "Substitution of Antithrombin III in Shock and DIC A Randomized Study", vol. 39, No. 1, pp. 81-89.
Joseph Loscalzo, Drugs, 1985, "Thrombolysis in the Management of Acute Myocardial Infarction and Unstable Angina Pectoris", pp. 192-204.
Ohno et al., Thrombosis Research, 1982, "Fibrinolytic System in Comparison with Herapin or Aprotinin", vol. 24, No. 5/6, pp. 445-452.
Triantaphyllopoulos, Thromb Haemostat, 1984, "Effects of Human Antithrombin III on Mortality and Blood Coagulation Induced in Rabbits by Endotoxin", pp. 232-235 vol. 51, No. 2.
Isobe, Advanced Exp. Med. Biol., 1979, "Inhibitory Effects of Gabexate Mesilate (Foy) on Experimental DIC" pp. 385-394.
Emerson, Jr., et al, Circulatory Shock, 1987, "Protection Against Disseminated Intravascular Coagulation and Death by Antithrombin-III in the Escherichia coli Endotoxemic Rat", pp. 1-13, vol. 21, 1987.
Diffang et al., Thrombosis Research, 1974, "Effect of Trasylol on Firbin Deposition and Elimination in the Lungs of Rats with Intravascular Coagulation Induced by Thrombin or Thromboplastin," vol. 5, pp. 263-276.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Anticoagulant substance obtained from urine and process for the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anticoagulant substance obtained from urine and process for the , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anticoagulant substance obtained from urine and process for the will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1156275

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.