Anticoagulant/sterilizing compositions and methods

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S256000

Reexamination Certificate

active

07132413

ABSTRACT:
Compositions and methods are provided for preventing formation of thrombosis on a liquid-contacting surface of a liquid delivery system, such as a port, catheter or port-catheter system. The liquid delivery system is connected to a patient for delivery of a liquid to the patient. The method involves contacting the surface with a thrombosis-preventing liquid containing taurolidine, taurultam or a mixture thereof, the thrombosis-preventing liquid further containing an anticoagulant agent. In an alternative embodiment, the liquid-contacting surface of the delivery system is contacted with a solution containing an anticoagulant agent, and thereafter contacted with a solution containing taurolidine, taurultam or a mixture thereof.

REFERENCES:
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patent: 5167960 (1992-12-01), Ito et al.
patent: 5362754 (1994-11-01), Raad et al.
patent: 6166007 (2000-12-01), Sodemann
patent: 196 06 897 (1997-08-01), None
patent: 9828027 (1998-07-01), None
patent: WO 98/28027 (1998-07-01), None
patent: WO 99/06114 (1999-02-01), None
patent: WO 00/01391 (2000-01-01), None
J. Reinmüller, The Effect of Taurolidine on Physiological and Pathological Blood Coagulation and Implications for its Use, Zentralblatt für Chifurgie 1999, Suppl 4:13-18 (translation)-pp. 1-13.
British Pharmacopoeia 1998, vol. 2, Appendix XVIII, pp. A266-A267.
Blenkharn, J.I., “The Antimicrobial Activity of Taurolin®—A Possible Additive for Parenteral Nutrition Solutions,”Clinical Nutrition(1987), vol. 6, No. 1, Feb. 1, 1987, pp. 35-38.
Jacobi, C.A. et al., “Intraperitoneal Instillation of Taurolidine and Heparin for the Prevention of Intraperitoneal Tumor Growth and Trocar Metastases in Laparoscopic Surgery in a Rat Model,”Langenbecks Arch Chir(1997), vol. 382, No. 4, Suppl. 1, Jul. 25, 1997 pp. S31-S36.
Johnston, D.A. et al., “Taurolin for the Prevention of Parenteral Nutrition Related Infection: Antimicrobial Activity and Long-Term Use,”Clinical Nutrition(1993), Dec. 1, 1993, vol. 12, No. 6, pp. 365-368.
Mughal, M., et al., “Infected Feeding Lines,”Care of Critically Ill, Nov. 1, 1990, vol. 6, No. 6, pp. 228-231.

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