Anticoagulant peptides

Details Anticoagulant peptides Anticoagulant peptides

1995-05-02

1996-02-27

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530324, 530326, A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

054950007

ABSTRACT:
This invention relates to peptide derivatives which are useful anticoagulant agents.

REFERENCES:
patent: 4792525 (1988-12-01), Ruoslahti et al.
Krstensnaky J. L. et al., "Development of MDL 28,050, a Small Stable Antithrombin Agent Based on Functional Domain of The Leech Protein, Hirudin", Thrombosis and Haemostasis (Stuttgart) 63(2) 208-214 (1990).
Krstenansky J. L. et al., "Comparison of Hirudin and Hirudin PA C-Terminal Fragments and Related Analogs as Antithromein Agents", Thrombosis Research 52; 137-141, (1988).
Krstenansky, et al., Chemical Abstracts vol. 109:231560t, p. 918, (1988).
Krstenansky J. L. et al., "Characterization of the Interaction of Thrombin with the C-terminal Region of the Leech Anticoagulent Peptide Hirudin", Peptides Chemistry and Biology, Proceed. of 10th American Peptide Sym., May (1987) pp. 447-448.
Hoffmann A. et al., "Inhibition of the Thrombin-Platelet Reaction by Hirudin", Haemostasis 14:164-169 (1984).
Krstenansky J. L. et al., "Anticoagulant Peptides: Nature of the Interaction of the C-Terminal Region of Hirudin with a Noncatalytic Binding Site on Thrombin", J. Med. Chem. 1987, 30, pp. 1688-1691.
Markwardt F. et al., "Comparative Studies on Thrombin Inhibitors in Experimental Microthrombisis", Thrombosis and Haemostasis (Stuttgart) 49 (3) 235-237 (1983).
Minar, et al., abstract of "Local Hirudin Application," Klin Wochenschr 63(4):190-1 (1985).
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Physicians Desk Reference Edward Barnhart Pub. 45th Ed. pp. 224 and 207 (1991).
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Krstenansky, et al., "Antithrombin Properties of C-terminus of Hirudin using Synthetic unsulfated N-acetyl-hirudin 45-65," FEBS Lett. 211 (1) 10-16 (1987).
Bajusz, et al., "Thrombin Inhibition by Hirudin Fragments: Possible Mechanism of Hirudin-Thromein Interaction," Peptides 32:473-476 (1984).
Dodt, et al., "The complete amino acid sequence of hirudin, a thrombin specific inhibitor," FEBS Letters 165(2), 180-84 (1984).
Owen, et al., "N-Terminal Requirements of Small Peptide Anticoagulants Based on Hirudin 54-65," J. Med. Chem., 31, 1009-1011 (1988).
Krstenansky, et al., "Characterization of the Interaction of Thrombin with the Carboxyl-terminal Region of the Leech Anticoagulant Peptide Hirudin," Peptides: Chemistry and Biology, 1987, pp. 447-448.
Rydel et al., "The Structure of a Complex of Recombinant Hirudin and Human a-Thrombin" Science vol. 249, pp. 277-280 (1990).
Krstenansky et al., "The C-Terminal binding domain of hirullin P18. Antithrombin activity and comparison to hirudin peptides" FEBS Letters, vol. 269, No. 2, pp. 425-429 (1990).
Krstenansky et al, Febs Letters, vol. 269, No. 2, pp. 425-429 (1990).

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