Anticoagulant hirudin variants and methods for their production

Details Anticoagulant hirudin variants and methods for their production Anticoagulant hirudin variants and methods for their production

1995-01-03

1998-06-16

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

514 15, 514 16, 530327, A61K 3808

Patent

active

057672350

ABSTRACT:
The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.
Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.
Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.

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