Anticholinergic compounds

Details Anticholinergic compounds Anticholinergic compounds

1972-11-22

1986-04-22

Miller, Edward A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546112, C07D45102, C07D22102

Patent

active

045843783

ABSTRACT:
Glycolic esters, useful as anticholinergic drugs, have the formula ##STR1## wherein R.sub.1 is selected from the class consisting of phenyl and cyclopentyl; R.sub.2 represents a hydrocarbon radical of 3 to 6 carbon atoms; Z is selected from the class consisting of --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- and --CH.sub.2 CH.dbd. and R.sub.3 represents an azacyclic ring selected from the class consisting of 1-methyltetrahydropyridine, 1-methyl-3-pyrroline, quinuclidine, 2-tropidine and 1-azabicyclo[2.2.2]oct-2-ene.

REFERENCES:
patent: 3725419 (1973-04-01), Judd et al.
Burger, "Drugs Affecting the Central Nervous System", vol. 2, pp. 128-132 and 139, Marcel Dekker, Inc. (Mar. 1968) N.Y.
Mutschler, Arzneimittel-Forsch., 16 (1), 73-5 (1966).
Zirkle et al., J. Org. Chem., 27, 1269-79 (1962).

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