Anticariogenic or antiperidontitic method

Details Anticariogenic or antiperidontitic method Anticariogenic or antiperidontitic method

1988-11-15

1990-08-14

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 536 24, 536 26, A61K 3170, C07H 1919, C07H 19167

Patent

active

049487833

ABSTRACT:
An anticariogenic or antiperiodontitic agent containing, as an active component, adenosine or its derivatives having an antibacterial activity against Streptococcus mutans or Bacteroides gingivalis. This anticariogenic or antiperiodontitic agent has strong inhibitory effects on the growth of Streptococcus mutans causing dental caries and Bacteroides gingivalis causing periodontitis and has neither influence on intestinal microflora nor any side-effects when orally administered.

REFERENCES:
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Sigma Chemical Co., Price List, Feb. 1984, St. Louis, Mo., 63178.
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Ishikawo, Chem. Abstr., vol. 104, No. 23, p. 629, No. 205873z, Jun. 9, 1986.
Schlenk, F., "Methylthioadenosine", Advances in Enzymology, vol. 54, pp. 195-265 (1983).
Efthymiou, C. and Hansen, P. A., "An Anticariogenic Analysis of Lactobacillus Acidophilus", J. Infect. Dis., vol. 110, pp. 258-267.
Chemical Abstracts, vol. 104, No. 23.
DE-A-617-590, (Laboratories Auclair), p. 1, 1 and 2.
FR-A-164-2 938 (Papierwerke Waldhof-Aschaffenburg AG) (GB-A-1422642), an English Language Counterpart of this French Patent.
J. Dent. Res., vol. 61, 1982, p. 206, No. 248, A. Al Abousy et al., "The Effects of Some Nucleotides on Dental Pulp".
Arch. Oral. Biol., vol. 24, No. 1, 1979, pp. 15-20, I. Laikko et al., "Adenosine Triphosphate in Normal and Carious Human Dentine".
Arch. Oral. Biol., vol. 24, No. 4, 1979, pp. 313-315, Y. Le Bell et al., "Adenosine-5'-Triphosphate Levels of the Human Tooth Pulp During Health and Disease".

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