Anticancer drug - antibody conjugates and method for preparing s

Details Anticancer drug - antibody conjugates and method for preparing s Anticancer drug - antibody conjugates and method for preparing s

1989-02-07

1991-05-07

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

530390, 530391, 530408, 530409, 530410, A61K 3944, A61K 1706

Patent

active

050135473

ABSTRACT:
A drug-protein conjugate of the general formula (I): ##STR1## where the moiety A--NH-- is the condensation product of an anticancer antibiotic having a free amino group, n is 0, 1 or 2, m is 0, 1, 2 or 3, the moiety --NHAB is the condensation product of a protein having a free amino group and the moiety ##STR2## is the condensation product of an amino acid of the formula HOOC--AA--NH.sub.2.

REFERENCES:
patent: 4543211 (1985-09-01), Kato et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4680338 (1987-07-01), Sundoro

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