Anticancer compounds and methods

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S330000

Reexamination Certificate

active

07148196

ABSTRACT:
The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human cells, is performed with invasion-inducing agents. Additionally, anti-cancer chemotherapeutics are described. Specifically, chemotherapeutic agents which have anti-metastatic and anti-growth properties are described including non-peptide compositions of matter.

REFERENCES:
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4018653 (1977-04-01), Mennen et al.
patent: 4424279 (1984-01-01), Bohn et al.
patent: 5051448 (1991-09-01), Shashoua
patent: 5136023 (1992-08-01), Hashino et al.
patent: 5169862 (1992-12-01), Burke, Jr. et al.
patent: 5192746 (1993-03-01), Lobl et al.
patent: 5264358 (1993-11-01), Doersen et al.
patent: 5436221 (1995-07-01), Kitaguchi et al.
patent: 5492890 (1996-02-01), Ginsburg et al.
patent: 5523209 (1996-06-01), Ginsburg et al.
patent: 5539085 (1996-07-01), Bischoff et al.
patent: 5548062 (1996-08-01), Isoai et al.
patent: 5559103 (1996-09-01), Gaeta et al.
patent: 5576423 (1996-11-01), Aversa et al.
patent: WO 95/24471 (1995-09-01), None
patent: WO 96/12823 (1996-05-01), None
P. Calabresi and B.A. Chabner, “Antineoplastic Agents,”In: Goodman and Gilman; The Pharmacological Basis of Therapeutics(Pergamon Press, 8th Edition) (pp. 1209-1216).
J.H. Gerlach, et. al., “Multidrug Resistance,”Cancer Surveys, 5:25-46 (1986).
J.H. Goldie and Andrew J. Coldman, “The Genetic Orgin of Drug Resistance in Neoplasms: Implications for Systemic Therapy,”Cancer Research, 44:3643-653 (1984).
D. Livant et al., “Invasion of Selectively Permeable Sea Urchin Embryo Basement Membranes by Metastatic Tumor Cells, But Not By Their Normal Counterparts,”Cancer Research55:5085 (1995).
Bresalier et al., “The Laminin 1 Chain Ile-Lys-Val-Ala-Val (IKVAV)-Containing Peptide Promotes Liver Colonization by Human Colon Cancer Cells,”Cancer Research55:2476 (1995).
Eldred et al., “Orally Active Non-Peptide Fibrinogen Receptor (GpIIb/IIIa)Antagonists: Identification of 4-[4-[4-(Aminoiminomethyl) phenyl]-1-piperazinyl]-1-piperidineacetic Acid as a Long-Acting, Broad-Spectrum Antithrombotic Agent,”J. Med. Chem., 37:3882 (1994).
Ku et al., “Potent Non-Peptide Fibrinogen Receptor Antagonists Which Present An Alternative Pharmacophore,”J. Med. Chem., 38:9 (1995).
W.R. Pearson and D.J. Lipman, “Improved Tools For Biological Sequence Comparison,”Proc. Natl. Acad. Sci. (USA), 85:2444-2448 (1988).
D.J. Lipman and W.R. Pearson, “Rapid and Sensitive Protein Similarity Searches,”Science, 227:1435-1441 (1985).
Douillard and Hoffman, “Basic Facts about Lymphocytes Hybridomas,”Compendium of Immunologyvol. II, ed. by Schwartz, pp. 119-141 (1981).
G. Kohler and C. Milstein, “Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity,”Nature, 256:495-497 (1975).
G. Kohler and C. Milstein, “Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines By Cell Fusion,”European Journal of Immunology, 6:511-519 (1976).
C.L. Reading, “Theory and Methods For Immunization in Culture and Monoclonal Antibody Production,”Journal of Immunological Methods, 53:261-291 (1982).
Ethier, S. P. et al., “Differential Isolation of Normal Luminal Mammary Epithelial Cells and Breast Cancer Cells from Primary and Metastatic Sites Using Selective Media,”Cancer Research, 53:627-635 (1993).
Stone, K. R. et al., “Isolation of a Human Prostate Carcinoma Cell Line (DU 145),”Int. J. Cancer, 21:274-281 (1978).
T.K. Gartner et al., “The Tetrapeptide Analogue of the Cell Attachement Site of Fibronectin Inhibitis Platelet Aggregation and Fibrinogen Binding to Activated Platelets,”The Journal of Biological Chemistry, 260:11891-11894.
N.S. Nicholson et al., “In Vitro and In Vivo Effects of a Peptide Mimetic (SC-47643) of RGD As An Antiplatelet and Antithrombotic Agent,”Thrombosis Research, 62:567-578 (1995).
M. Nomizu et al., “Multimeric Forms of Tyr-Ile-Gly-Ser-Arg (YIGSR) Peptide Enhance the Inhibition of Tumor Growth and Metastasis,”Cancer Research, 53:3459-3461 (1993.
I. Saiki et al., “Inhibition of the Metastasis of Murine Malignant Melanoma By Synthetic Polymeric Peptides Containing Core Sequences of Cell-Adhesive Molecules,”Cancer Research, 49:3815-3822 (1989).
R.H. Wenger et al. “Cloning of cDNA Coding For Connective Tissue Activating Peptide III From a Human Platelet-Derived AgtII Expression Library,”Blood, 73(6):1498-1503.
S. Aota, et al., “The short Amino Acid Sequence Pro-His-Ser-Arg-Asn in Human Firbronection Enhances Cell-adhesive Function,”J. of Biol. Chemistry, vol. 269,40:24756-24761 (1994).
S. Kumar et al., “Childhood kidney tumours: in vitro studies and natural history,”Virchows Arch, 405:95-111 (1984).
M. O. Dayhoff, “Atlas of Protein Sequence and Structure”Natl. Biomed. Res. Foundation, Wash. D.C. 5:96 (1972).
Z. Song et.al., “A Novel Cysteine-rich Sequence-specific DNA-binding Protein Interacts with the Conserved X-box Motif of the Human Major Histocompatibility Complex Class II Genes Via a Repeated Cys-His-Domain and Functions as a Transcriptional Repressor,”Journal of Experimental Medicine, 180:1763-1774 (1994).
H P. Hershey et. al., “Analysis of cloned cDNA and genomic sequences for phytochrome: complete amino acid sequences for two gene products expressed in etiolatedAvena,” Nucleic Acids Research, 13: 8543-8559 (1985).

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