Anticancer compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514374, 514378, 514438, 514440, 514467, 514471, 514474, 514646, 514688, 548215, 548240, 549 39, 549 83, 549 74, 549315, 536 11, 536120, A61K 31335

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active

048747807

ABSTRACT:
Deuterated aromatic aldehydes of the formula: ##STR1## where Ar is substituted phenyl, and derivatives thereof represented by the formula: ##STR2## where Ar is substituted or unsubstituted phenyl, and X.sub.1 and X.sub.2 are substituted hetero atoms or together with the carbon to which they are attached from a heterocycle. These compounds are useful as anticancer agents.

REFERENCES:
patent: 4146651 (1979-03-01), Bharucha et al.
patent: 4297289 (1981-10-01), DeLuca et al.
patent: 4423236 (1983-12-01), Welebir
Kochi et al., "Anti-tumor agent comprising O-benzylidene-L-ascorbic acid or its salt" CA 103 215728z (1985).
Atchley et al. "Synthesis of 5,6-O-alkylidene derivatives of L-ascorbic acid by the orthoformate method" CA 76 154065 f (1972).
Lilly "Ascorbic acid ethers" CA 100 34783f (1984).

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