Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2006-01-23
2008-09-09
Price, Elvis O (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C560S156000, C560S183000, C560S219000, C560S225000, C560S226000, C514S533000, C514S423000, C514S408000, C514S315000, C514S357000, C514S438000, C514S471000, C514S534000, C549S061000, C549S062000, C549S068000, C549S315000
Reexamination Certificate
active
07423170
ABSTRACT:
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g. a farnesyl group) is attached to the protein in the presence of an enzyme (e.g. farnesyl protein transferase). Deactivation of the prenylation enzyme through covalent modification can therefore ultimately result in the mitigation and/or cessation of cancer cell growth. Various prenylation inhibitors having the necessary structural groups to bond covalently, or essentially irreversibly, to the prenylation enzyme include carbonyl or thiocarbonyl compounds (or masked versions of these compounds) and alpha oxo-epoxides bonded to a hydrophobic, substrate-mimicking group. The carbonyl or thiocarbonyl compounds also contain a nucleofugal atom or group to enhance the tendency to form covalent bonds.
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Hartman Rosemarie F.
Kim Ann Y.
Lefler Scott R.
Okolotowicz Karl J.
Ottersberg Steven R.
Arizona Biomedical Research Commission
Banner & Witcoff , Ltd.
Price Elvis O
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