Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2006-03-14
2006-03-14
Gitomer, Ralph (Department: 1655)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C435S015000, C435S029000
Reexamination Certificate
active
07012097
ABSTRACT:
Prenylating enzymes are involved in modifying oncoproteins, such as RAS, so that growth of neoplastic cells becomes uncontrolled. Inactivation of such enzymes can prevent uncontrolled growth. α-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate.
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Hartman Rosemarie
Lefler Scott
Okolotowicz Karl J.
Ottersberg Steven R.
Robinson Dale E.
Banner & Witcoff , Ltd.
Gitomer Ralph
The Arizona Disease Control Research Commission
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