Anticancer agent

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C514S012200, C530S324000

Reexamination Certificate

active

11162817

ABSTRACT:
The present application discloses a method of reducing tumor growth that includes contacting the tumor with a tumor growth reducing effective amount of a composition comprising LK8 or LK68 protein or a functionally equivalent amino acid variant thereof and a pharmaceutically acceptable carrier thereof to a subject having tumor.

REFERENCES:
patent: 5639725 (1997-06-01), O'Reily et al.
patent: 5801012 (1998-09-01), Soff et al.
patent: 5801146 (1998-09-01), Davidson
patent: 5945403 (1999-08-01), Folkman et al.
patent: 6743428 (2004-06-01), Chang et al.
patent: 7118905 (2006-10-01), Chang et al.
patent: WO 2004/073730 (2004-09-01), None
Mikol V, et al., 1996, Crystal structures of apolipoprotein(a) kringle IV37 free and complexed with 6-aminohexanoic acid and with p-aminomethylebenzoid acid: existence of novel and expected binding modes. J Mol Biol. 256(4):751-61.
Burgess et al., 1990, Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding growth factor-1 from its receptor-binding activites by site-directed mutagenesis of a single lysine residue. J Cell Biol. 111:2129-2138.
Bowie Ju et al., 1990, Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science. 247 (4948):1306-1310.
Fogarty M., 2002, Learning from Angiogenesis Trial Failures. The Scientist 16:33.
Fan TP et al., 1995, Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci. 16:57-66.
Wallace RW, 1998, Media hype and drug discovery Drug Discovery Today, 3(10):433-434.
Cao Y et al., 1997, Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth. J Biol Chem. 272:22924-22928.
Kraft HG et al., 1995, Sequence polymorphism in kringle IV 37 in linkage disequilibrium with the aopolipoprotein (a) size polymorphism Hum Genet. 95(3):275-282.
McLean et al., 1987, cDNA sequence of human apolipoprotein(a) is homologous to plaminogen. Nature 330(6144):132-7.
Lou, X. J. et al., 1998, Despite Its Homology to Angiostatin Apolipoprotein(a) Does Not Affect Angiogenesis, Exp. Mol. Pathol., 65:53-63.
LoGrasso, P. V. et al., 1994, Cloning, Expression, and Characterization of Human Apolipoprotein (a) Kringle IV37, J. Biol. Chem., 269(34):21820-21827.
Scanu, A. M. and Edelstein, C., 1994, Apolipoprotein(a): structural and functional consequences of mutations in kringle type 10 (or kringle 4-37), Clinical Genetics, 46:42-45.
Scanu, A. M. et al., 1994, A single point mutation (Trp 72 {dot over (a)} Arg) in human apo (a) kringle 4-37 associated with a lysine binding defect in Lp(a), Biochimica et Biophysica Acta, 1227:41-45.
Gabel, B. R. and Koschinsky, M. L., 1998, Sequences within Apolipoprotein(a) Kringle IV Types 6-8 Bind Directly to Low-Density Lipoprotein and Mediate Noncovalent Assocation of Apolipoprotein(a) and Apolipoprotein B-100, Biochemistry, 37:7892-7898.

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